Ci at yii ñu weesu, peptides yi dañuy nekk barab bu ñuy gëstu ci wàllu wérgi-yaram ndax seen liggéey bu baax ak seen kaaraange. Xeetu peptide bu ndaw boobu dafay boole asid amino yi, di yamale metabolism bi, di tere ku am doole wala di gëna dooleel decomposition grees yi. Jumtukaay bi amul fenn mooy wane wuute gi am ci liggéey bi, te xam limu nekk ci wàllu chimik lu am solo la ci defar ay produit yu bees ci wàllu dagg.
Ci wàllu molekuleer, peptides yiy dagg dañuy faral di boole 2-20 asid amino, te guddaayu chaine bi dafay indi jafe-jafe ci liggéeyam ak stabilite. Ci misaal, yenn peptides yu gàtt yu gàtt (lu melni 3{6} 5 asid amino) mën nañu dugg ci barrier mbàq yi, te dañuy jëfandikoo direct ci reseptëri adipocyte yi; ak peptides yu gëna gudd (lu melni 10-20 asid amino) mën nañu wàññi satiyyaate ci simulation siñaal hormone (lu melni peptide-1 bu nuru glucagon).
Coppite yiñ wara def mooy gëna am solo ngir gëna baaxal njariñu peptides yiy dagg. Saytukatt yi dañuy gëna yokk bioavailability peptide yi ci wecci asid amino yu amul benn (lu melni soppi asid amino hydrophobic ak hydrophilic yi), dugal ay jumtukaayi cyclic wala yokk ay grupu aar. Ci misaal, xaralay cyccization mën na tere enzyme bi yàqu ba noppi yokk diiru jëf ci vivo; N-terminal coppite mën na wàññi li ñuy woowe renard bi ba noppi yokk limu drog ci deret ji.
Difference yi ci structure yi ci poids {-los peptides dafay indi itam wuute ci mekaniism yiñy teg. Yenn peptide yi dañuy gëna dooleel oxidation grees yi ci def yoon AMPK, te seen structure core dañuy faral di am {{2}chain asid amino (lu melni leucine); ñeneen ñi dañuy nuru hormone yu mbàq yi, te dañu soxla méngoo bu baax ci barab yi ñuy lëkkaloo ak reseptër yi. Nuru peptide yu mel noonu, lu ëpp 90%.
Gëstu bi fi nekk mingi lalu ci jàngat bu leer ci structure-uction. Ak ndimbalu simulation ordinatër ak xaralay resonance magnetik nucleaire, gëstukat yi mën nañu wax luy indi coppite ci asid amino yi ci liggéey bi, ba noppi gaawlu defar poids yu bees {2}loss peptides. Ak jëm kanam gi ci biologie synthetik, mën nañu ko méngale ak chaîne peptide yuñ personaalise ci ëlëg ngir mëna faj bëgg-bëggu nit ñi am xeetu metabolik yu wuute.
Li gëna am solo ci wàllu poids).